Clinical Efficacy of Polyglutamate via Microneedle Delivery: A Novel Non-Invasive Therapy for Androgenetic Alopecia

    February 2026 in “ Archives of Dermatological Research ”
    Lina Jin, Songling Yao, Hui Zhang … Shuai Huang
    Studysummary In this study, microneedle-assisted delivery of polyglutamate significantly improved hair parameters, scalp symptoms, and quality of life in androgenetic alopecia patients, with no serious adverse reactions reported.
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    Research cited in this study 14

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    8. Polyglutamate: Unleashing the Versatility of a Biopolymer for Cosmetic Industry Applications Cosmetics · 2024
    9. Autologous Platelet-Rich Plasma Treatment for Androgenic Alopecia: A Systematic Review and Meta-Analysis of Clinical Trials on Patient Safety, Efficacy and Outcomes Plastic and Reconstructive Surgery · 2022
    10. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    11. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version Journal of The European Academy of Dermatology and Venereology · 2017
    12. In Vivo Hair Growth Promotion Effects of Ultra-High Molecular Weight Poly-γ-Glutamic Acid from Bacillus Subtilis (Chungkookjang) Journal of Microbiology and Biotechnology · 2015
    13. Hair: What Is New in Diagnosis and Management? Dermatologic Clinics · 2012
    14. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010