Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals

October 2024 in “ Molecular Pharmaceutics ”

B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Raghu Raj Singh Thakur, Ryan F. Donnelly, Lalitkumar K. Vora

microneedles transdermal delivery phytochemicals alopecia EGCG quercetin hair follicle stem cells green tea extract

Studysummary This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Microneedles (MNs) are a promising technology for enhancing the transdermal delivery of phytochemicals, offering improved bioavailability and reduced systemic side effects. They effectively bypass the skin barrier, making them suitable for treating conditions like alopecia, cancer, and chronic wounds. MNs come in various forms, such as solid, coated, hollow, dissolving, and hydrogel-forming, each with unique benefits. In alopecia, MNs enhance the delivery of compounds like EGCG and quercetin, promoting hair growth by activating hair follicle stem cells. Despite their potential, challenges like manufacturing inconsistencies and the need for further clinical studies remain. Overall, MNs represent a significant advancement in transdermal drug delivery, with potential applications in various therapeutic areas.

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