Fabrication of Polyvinyl Pyrrolidone-K90/Eudragit RL100-Based Dissolving Microneedle Patches Loaded with Alpha-Arbutin and Resveratrol for Skin Depigmentation

    January 2023 in “ Biomaterials Science ”
    Nway Nway Aung, Supusson Pengnam, Tanasait Ngawhirunpat, Theerasak Rojanarata, Prasopchai Patrojanasophon, Praneet Opanasopit, Boonnada Pamornpathomkul
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    Studysummary This study investigated the use of dissolving microneedle patches to improve the skin-lightening effects of alpha-arbutin and resveratrol, finding that the patches enhanced intradermal delivery and slightly decreased the melanin index without affecting skin hydration or causing irritation over 24 hours. Our plain-language summary of this paper — not a Tressless recommendation.
    This study explored the use of dissolving microneedle (DMN) patches made from polyvinyl pyrrolidone-K90/Eudragit RL100 to enhance the delivery of alpha-arbutin (AA) and resveratrol (Res) for skin depigmentation. The patches, particularly the F3 formulation with a 5:1 ratio of 10% AA to 2% Res, demonstrated improved intradermal delivery, achieving approximately 2.6 times higher absorption than a cream formulation. The patches were effective in slightly reducing the melanin index without causing skin irritation, and they did not affect skin hydration, transepidermal water loss, or elasticity. The study concluded that AA/Res-loaded DMN patches could be a promising method for delivering cosmetic agents for skin depigmentation.
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