This review discusses the variability of human skin pigmentation and melanin synthesis, influenced by genetics, UV exposure, and certain drugs, and how these factors contribute to conditions like hyperpigmentation and hypopigmentation. Common disorders include albinism, melasma, vitiligo, Addison’s disease, and post-inflammatory hyperpigmentation. Treatments involve anti-inflammatory medications, antioxidants, and tyrosinase inhibitors, with options for oral and topical applications. The review highlights the importance of consulting a doctor before starting treatments and examines 25 plants, 4 marine species, and 17 clinically tested medications available for treating skin pigmentation disorders.
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December 2022 in “Journal of applied biological chemistry” TRP-hair essence protects hair from heat damage, maintains color, and strengthens hair.
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July 2022 in “PubMed” Coconut oil helps with brittle hair and infestations, castor oil may improve hair shine, and argan oil lacks evidence for hair benefits.
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May 2021 in “Polymers” Jojoba oil is highly valued for its diverse medicinal and industrial uses.
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April 2019 in “Journal of Cosmetic Dermatology” Herbal alternatives like saw palmetto and green tea may offer safe, effective treatment for hormonal hair loss.
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January 2018 in “Cosmetics” Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.
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February 2017 in “Journal of the American Academy of Dermatology” JAK inhibitors help with skin conditions but need more research on dosing and safety.
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December 2015 in “Journal of the American Academy of Dermatology” A man with vitiligo and alopecia saw quick skin and hair improvement with ruxolitinib, but skin color gains were lost after stopping treatment.
April 2024 in “Journal of translational medicine” Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
February 2024 in “International Journal For Multidisciplinary Research” Nanostructured lipid carriers are effective for treating hyperpigmentation in women aged 30-40.
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November 2022 in “Future Journal of Pharmaceutical Sciences” Liposome-based cosmeceuticals improve treatment effectiveness for skin and hair conditions.
The document is a detailed guide on skin conditions and treatments for dermatologists.
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February 2013 in “Central European Journal of Biology” Melanocytes are diverse cells important for pigmentation and skin health, influenced by genetics and environment.
