Platinum-Induced Peripheral Neuropathy: ROS-Related Mechanism, Therapeutic Agents, and Nanosystems

The document reviewed the mechanisms and potential treatments for platinum-induced peripheral neuropathy (PIPN), emphasizing the role of reactive oxygen species (ROS) in its development. It highlighted the promise of antioxidant drugs, traditional medicines, and nanotechnology-based approaches in reducing oxidative stress and alleviating PIPN symptoms. Various nanosystems, including Pt prodrugs and anti-ROS nanoparticles, were explored for their ability to enhance tumor-targeting efficiency and minimize neurotoxicity. Despite advancements, PIPN remained a significant clinical challenge, necessitating further research to balance the antitumor efficacy of platinum drugs with the reduction of their neurotoxic side effects.