First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide

This study presents microbial-derived polydeoxyribonucleotide (L-PDRN) from Lactobacillus rhamnosus as a sustainable and enhanced alternative to traditional salmon-based PDRN. L-PDRN features smaller DNA fragments, which improve skin absorption and bioavailability, making it particularly effective for skin regeneration and wound healing. It demonstrates superior antioxidant activity, reducing oxidative stress more effectively than traditional PDRN, and shows enhanced regenerative potential by promoting cell migration and wound closure under inflammatory conditions. L-PDRN also exhibits greater immunostimulatory and anti-inflammatory properties, with unique signaling mechanisms expanding its therapeutic potential. The use of Lactobacillus as a microbial source offers advantages such as year-round availability, sustainability, and reduced environmental impact, supporting large-scale production. This research highlights L-PDRN as a versatile and effective biomaterial for applications in skin care, wound healing, oxidative stress management, and immune modulation.