First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide

January 2025 in “ Current Issues in Molecular Biology ”

Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae‐Jung Kang, Chun‐Woong Park, Jongsung Lee, Won-Sang Seo

polydeoxyribonucleotide L-PDRN Lactobacillus rhamnosus antioxidant activity wound healing immunostimulatory effects bioavailability signaling pathways oxidative stress management tissue regeneration immune modulation

Studysummary This study found that PDRN derived from Lactobacillus rhamnosus showed superior antioxidant and wound-healing properties compared to salmon-derived PDRN, while also offering potential benefits in immune modulation and bioavailability.

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In this study, classic PDRN (50-1,500 kDa) was observed to improve wound healing quality in a mouse model by enhancing collagen composition and cell migration.

research Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide

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research Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster

18 citations , September 2016 in “International Journal of Molecular Sciences”

This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.

research The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

128 citations , March 2016 in “Advanced Pharmaceutical Bulletin”

This study found that sub-100 nm size solid lipid nanoparticles showed the most effective skin penetration and depth, mainly via hair follicles, in rat skin.

research Therapeutic Efficacy of Autologous Platelet-Rich Plasma and Polydeoxyribonucleotide on Female Pattern Hair Loss

54 citations , December 2014 in “Wound Repair and Regeneration”

This study observed that autologous PRP and PDRN injections improved hair thickness and density in women with pattern hair loss, with combined therapy showing greater improvement in thickness than PDRN alone.