Microneedles in Improving Skin Appearance and Enhanced Delivery of Cosmeceuticals

The document from 2018 discusses the effectiveness and potential of microneedle (MN) technology in the cosmeceutical industry for skin rejuvenation and the enhanced delivery of active ingredients. It outlines the evolution of MN devices, such as the Dermaroller® and its variants, and newer models like the Dermapen 3™ and MDerma™ FDS, which offer improved performance and safety. The document reports on studies demonstrating the benefits of MNs in increasing collagen production, treating skin conditions, and enhancing the penetration of cosmeceuticals like epigallocatechin-3-gallate and ascorbic acid. It also highlights the importance of safety and proper use, noting that while MNs are generally well-accepted and cause minimal irritation, there is a need for proper sterilization and the use of licensed products. Studies involving 45 women with facial hyperpigmentation and others with 24 and 51 women evaluating anti-wrinkle effects showed positive results with MN use. Additionally, a study on 25 women combining microneedling with stem cell-derived treatments and another on 20 patients using fractional radiofrequency microneedling indicated improvements in wrinkles and pigmentation. The document concludes that MN devices are becoming more commercialized and regulated, with ongoing innovation expected in the field.