Homocysteine in Androgenetic Alopecia: A Case Control Study and Observational Experiments on Mice

This study found that elevated homocysteine (HCY) levels are positively correlated with androgenetic alopecia (AGA) in both humans and mice. In a case-control study involving 528 AGA patients and 500 healthy controls, AGA patients had higher mean serum HCY levels, with hyperhomocysteinemia more prevalent among them. Observational experiments on mice showed that increased HCY levels impaired hair growth. The study suggests a potential link between hyperhomocysteinemia and hair loss, indicating that HCY might play a role in the pathogenesis of AGA, though further research is needed to understand the specific mechanisms.