In this study, researchers found that FGF9 plays a significant role in sheep wool growth by accelerating the proliferation and cell cycle of dermal papilla cells, potentially through regulation of the Wnt/β-catenin signaling pathway.
December 2022 in “PubMed” This study observed that one-third of men with early-onset androgenetic alopecia had altered hormonal profiles, which were associated with increased insulin resistance and more severe hair loss.
October 2022 in “The Journal of Clinical Pharmacology” This study found that men with early-onset androgenic alopecia are less responsive to the cardiometabolic effects of bromocriptine compared to men with normal hair growth.
October 2022 in “International Journal of Molecular Sciences” This study found that collagen peptides from Mozambique tilapia significantly promoted hair regrowth and increased the proliferation of hair growth factors in vitro and in vivo, suggesting potential as supplements for hair loss prevention.
3 citations
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November 2021 in “Journal of The American Academy of Dermatology” This article discusses hormonal mechanisms underlying androgenetic alopecia but does not report any new findings; it reviews the roles of dihydrotestosterone and available FDA-approved treatments.
2 citations
,
July 2021 in “Journal of Cardiovascular Pharmacology” This study suggests that lisinopril's cardiometabolic effects are weaker in men with early-onset male-pattern baldness compared to those with normal hair growth.
June 2021 in “The American Journal of the Medical Sciences” This study found that patients with androgenetic alopecia had higher serum homocysteine levels, linked to the mutant MTHFR genotype, and an increased risk of coronary heart disease.
3 citations
,
May 2021 in “Molecules” This study found that men with early-onset androgenetic alopecia may experience less benefit from rosuvastatin treatment in terms of improving cardiometabolic risk factors compared to men with normal hair growth.
23 citations
,
January 2020 in “Frontiers in Pharmacology” In this study, DHT was observed to have varying effects on hair follicle growth and related protein expression depending on concentration, with the Wnt/β-catenin pathway potentially playing a significant role.
66 citations
,
June 2018 in “International Journal of Women's Dermatology” This article discusses treatments for female pattern hair loss, highlighting that oral antiandrogens and topical minoxidil can effectively arrest progression and reverse miniaturization in many patients with mild-to-moderate cases, but it reports no new clinical results.
24 citations
,
December 2014 in “International Journal of Molecular Medicine” In this study, researchers found that petroleum ether extract of Eclipta alba significantly stimulated follicular keratinocyte proliferation and reduced TGF-β1 expression in nude mice, suggesting potential use for certain types of alopecia.
18 citations
,
October 2014 in “Indian Journal of Dermatology” This study found that patients with alopecia areata have lower levels of RBC folate, correlating negatively with the disease's severity and extent.
5 citations
,
January 2013 in “Cells Tissues Organs” This study found that activin B promotes the initiation and development of hair follicles in both cultured and neonatal mouse skin models.
24 citations
,
January 2013 in “Indian Dermatology Online Journal” This study found that males with androgenetic alopecia had a higher risk of coronary artery disease, with significant differences in several lipid and blood pressure markers compared to controls.
110 citations
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July 2010 in “Journal of The American Academy of Dermatology” Hair loss linked to higher heart disease risk in both men and women.
112 citations
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October 2005 in “Mayo Clinic Proceedings” This article reviews the clinical, psychological, and management aspects of androgenetic alopecia in men, stating that it can be effectively managed by generalist clinicians with pharmacotherapy and surgical advancements.
