MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case-Control Study

    F. A. Saafan, Ayman Z. Elsamanoudy, Dalia Shaalan, Nanees Zeidan, Mohammad A. Gaballah
    TLDR Androgenetic alopecia is linked to a higher risk of coronary heart disease due to certain genetic factors and high homocysteine levels.
    The study examined the link between androgenetic alopecia (AGA) and coronary heart disease (CHD), focusing on the MTHFR C677T polymorphism and serum homocysteine (SH) levels, involving 106 AGA patients and 100 healthy controls. It found that SH levels were significantly higher in AGA patients, especially those with the TT genotype of the MTHFR gene. The mutant T allele was associated with increased SH levels and a higher risk of CHD in AGA patients. The study concluded that AGA was linked to a higher risk of CHD due to elevated SH levels associated with mutant MTHFR genotypes, suggesting cardiac evaluation and follow-up for early detection and treatment of CHD in AGA patients.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 1000+ results

    Similar Research

    5 / 1000+ results