Methylenetetrahydrofolate Reductase C677T Mutation in Patients with Alopecia Areata in Turkish Population

The study investigated the association between the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and alopecia areata (AA) in the Turkish population. It included 136 AA patients and 130 healthy controls. Results showed that the CT and TT genotypes, as well as the T allele of the MTHFR C677T mutation, were significantly more prevalent in AA patients compared to controls, suggesting that this mutation may be a risk factor for developing AA. This was the first study to report such an association.