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research Nestin expression in hair follicle sheath progenitor cells

352 citations , August 2003 in “Proceedings of the National Academy of Sciences”

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

research Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

243 citations , October 2003 in “Developmental biology”

This study identified ectodin as a novel BMP inhibitor that modulates BMP signaling in ectodermal development by interacting with SHH and FGF pathways.

research Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing

176 citations , August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.

research Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

138 citations , June 2012 in “Genes & Development”

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

research Effects of shampoo and water washing on hair cortisol concentrations

122 citations , October 2010 in “Clinica Chimica Acta”

In this study, washing rhesus monkey hair with water or shampoo significantly reduced cortisol levels, suggesting potential underestimation of chronic stress hormone deposition in hair due to washing.

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learn sh-Polypeptide-7

What is sh-Polypeptide-7 and why is it used in some advanced hair serums and treatments? sh-Polypeptide-7 is a synthetic peptide that supports hair growth and scalp regeneration.
How does sh-Polypeptide-7 help stimulate hair follicle activity or reduce scalp inflammation? sh-Polypeptide-7 is the INCI name for a lab-made form of human growth hormone (somatotropin) — not EGF, which is sh-Oligopeptide-1. Growth hormone and IGF-1 signalling is documented in hair follicle biology, but there is no published human trial of sh-Polypeptide-7 applied to the scalp for hair growth or scalp inflammation.
Is sh-Polypeptide-7 considered a natural or synthetic ingredient, and how is it typically applied? sh-Polypeptide-7 is a synthetic ingredient applied in hair-care products.
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community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Should I stop creatine or is it fine to still using it ?

13 upvotes 1 year ago

An 18-year-old with hair thinning is using minoxidil and considering stopping creatine due to concerns about increased DHT and hair loss. Opinions on creatine's impact are mixed, and the user plans to stop it until they can access topical finasteride.

community Shed switching from fin to dut?

in Finasteride/Dutasteride 10 upvotes 2 years ago

A user has been on finasteride for over 1.5 years but is still losing hair, so they're switching to dutasteride and taking both for 3 months before stopping finasteride. They're concerned about potential hair shedding during the switch even when done correctly.

community What I've learned about shedding after being on Dut + Min for 2yrs

37 upvotes 3 days ago

Shedding is a normal part of hair regrowth when using treatments like Dutasteride and Minoxidil, and it can take up to two years for shedding to stabilize and hair to fully recover. Patience is crucial, as initial shedding doesn't mean the treatment isn't working.

community sharing my experience using Fin/Dut + minoxidil to treat alopecia.

31 upvotes 5 days ago

Using finasteride/dutasteride with minoxidil can help stop hair loss and regrow some hair, but stopping minoxidil may lead to rapid shedding. Unrealistic expectations can affect perception of treatment effectiveness.

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