Gender Difference in Hair Length Revealed by CRISPR-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations

October 2022 in “ International Journal of Molecular Sciences ”

Ryo Takahashi, Gou Takahashi, Yuichi Kameyama, Masahiro Sato, Masato Ohtsuka, Kenta Wada

CRISPR FGF5 Fgf5 mutant mice anagen phase androgen receptor hair cycle regulation frameshift mutations CRISPR gene editing fibroblast growth factor 5 hair growth phase male hormone receptor

Studysummary This study found that Fgf5 mutant mice exhibited longer hair, particularly in males, likely due to a prolonged anagen phase in the hair cycle.

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research Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae

32 citations , February 2024 in “Growth Hormone & IGF Research”

In this study, DHT was found to inhibit hair growth in mice by decreasing IGF-I production in dermal papillae through reduced sensory neuron stimulation.

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations , October 2021 in “Cells”

This review discusses the potential of miRNA-mediated hair growth treatments for androgenetic alopecia by targeting DKK1 to modulate the Wnt/β-catenin signaling pathway and reports no new clinical findings.

research Expression and Function of FGF5 Isoform in Hair Growth

1 citations , February 2021 in “Scholars international journal of anatomy and physiology”

In a laboratory setting, this study found that overexpression of the FGF5 short form in cultured keratinocytes increased hepatic growth factor gene expression, suggesting a potential role in hair growth.

Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

research Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia

23 citations , January 2021 in “Biomedicine & Pharmacotherapy”

This study found that dihydrotestosterone induced hair loss and changes in hair morphology in male C57BL/6 mice, effects that could be partially reversed by the AR antagonist bicalutamide.

research Hormonal Effects on Hair Follicles

102 citations , July 2020 in “International journal of molecular sciences”

This review discusses the effects of hormonal changes on hair follicles, concluding that hormones like androgens and estradiol significantly influence hair growth and cycle, while the roles of other hormones are still being researched.

research Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep

23 citations , May 2020 in “Cell Death and Disease”

This study generated FGF5-knockout Dorper sheep using the CRISPR/Cas9 system, resulting in significantly increased fine-wool and active hair-follicle density, and explored downstream signaling pathways for potential applications in androgen alopecia treatment.

CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

research CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen

13 citations , March 2020 in “Genes”

This study found that FGF5-/- rabbits exhibited a significant long hair phenotype by prolonging the anagen phase, suggesting FGF5 acts as a negative regulator of hair growth.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations , September 2017 in “Molecular and Cellular Endocrinology”

This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.

Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

research Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia

47 citations , October 2016 in “Molecular and Cellular Endocrinology”

This study found that DKK1 and WNT10b are paracrine factors that modulate hair follicle stem cell differentiation inhibition, contributing to androgenetic alopecia by affecting Wnt signaling in androgen-sensitive dermal papilla cells after dihydrotestosterone stimulation.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

42 citations , September 2015 in “Gene”

This study demonstrated that FGF5s acts as an inhibitor of FGF5 in regulating hair growth cycles in cashmere goat dermal papilla cells.

research Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice

64 citations , January 2015 in “BioMed Research International”

In this study, topical application of fibroblast growth factors was found to promote hair growth by inducing and prolonging the anagen phase in telogenic C57BL/6 mice, suggesting potential as hair growth-promoting agents.

research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations , July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

This study identified mutations in the FGF5 gene as a cause of extreme eyelash growth in Pakistani families, highlighting a potential target for regulating eyelash growth.

research Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox

98 citations , February 2007 in “Seminars in Cell & Developmental Biology”

This review explores the hormonal regulation of hair growth and changes with season, age, and sexual development, and calls for improved treatments for hair disorders.

research Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression

69 citations , May 1997 in “Veterinary Pathology”

This study found that the angora mouse mutation prolongs the anagen phase, resulting in excessively long hair and follicular abnormalities, without involving circulating hair cycle factors.

research The Hair Cycle on the Human Thigh and Upper Arm

67 citations , July 1985 in “British journal of dermatology/British journal of dermatology, Supplement”

This study found that males have significantly longer hair on their thighs compared to females, mainly due to a longer anagen phase and a greater rate of growth.

research Endocrine Influences on Hair Growth

68 citations , March 1965 in “The BMJ”

Hormones and genetics affect hair growth and patterns, with some changes reversible and others not.