Gender Difference in Hair Length Revealed by CRISPR-Based Production of Long-Haired Mice with Dysfunctional FGF5 Mutations

    October 2022 in “ International Journal of Molecular Sciences ”
    Ryo Takahashi, Gou Takahashi, Yuichi Kameyama … Kenta Wada
    Studysummary This study found that Fgf5 mutant mice exhibited longer hair, particularly in males, likely due to a prolonged anagen phase in the hair cycle.
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    Research cited in this study 16

    1. Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae Growth Hormone & IGF Research · 2024
    2. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    3. Expression and Function of FGF5 Isoform in Hair Growth Scholars international journal of anatomy and physiology · 2021
    4. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    5. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    6. Crosstalk Between Androgen and Wnt/β-Catenin Leads to Changes in Wool Density in FGF5-Knockout Sheep Cell Death and Disease · 2020
    7. CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen Genes · 2020
    8. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    9. Androgens Modify Wnt Agonists/Antagonists Expression Balance in Dermal Papilla Cells Preventing Hair Follicle Stem Cell Differentiation in Androgenetic Alopecia Molecular and Cellular Endocrinology · 2016
    10. Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats Gene · 2015
    11. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    12. FGF5 Is a Crucial Regulator of Hair Length in Humans Proceedings of the National Academy of Sciences of the United States of America · 2014
    13. Hormonal Regulation of Hair Follicles Exhibits a Biological Paradox Seminars in Cell & Developmental Biology · 2007
    14. Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression Veterinary Pathology · 1997
    15. The Hair Cycle on the Human Thigh and Upper Arm British journal of dermatology/British journal of dermatology, Supplement · 1985
    16. Endocrine Influences on Hair Growth The BMJ · 1965

    Related research 6

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    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
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