MiR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

April 2022 in “ Genes ”

Fan Yao, Bohao Zhao, Shuaishuai Hu, Shaocheng Bai, Rongshuai Jin, Chen Zhang, Yang Chen, Xinsheng Wu

miR-129-5p HOXC13 hair follicle growth SFRP2 TGF-β1 FGF2 dermal papilla cells apoptosis proliferation transforming growth factor beta 1 fibroblast growth factor 2

TLDR miR-129-5p affects hair growth by targeting the HOXC13 gene.

The study found that miR-129-5p played a significant role in hair follicle growth in Angora rabbits by targeting the HOXC13 gene. Overexpression of miR-129-5p was associated with reduced expression of hair follicle development-related genes and increased expression of genes like SFRP2, TGF-β1, and FGF2, similar to the effects of HOXC13 knockdown. Conversely, miR-129-5p knockout had effects akin to HOXC13 overexpression. Additionally, miR-129-5p promoted apoptosis and inhibited proliferation of dermal papilla cells, while its inhibition reduced apoptosis and promoted proliferation. These findings suggested that miR-129-5p could be crucial for understanding hair follicle development and might offer new approaches for diagnosing and treating hair loss in humans.

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MiR-129-5p Participates in Hair Follicle Growth by Targeting HOXC13 in Rabbit

Research cited in this study

research Skin Transcriptome Profiling of Changthangi Goats Highlights the Relevance of Genes Involved in Pashmina Production

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

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research TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

research Post-Transcriptional Regulation of Keratinocyte Progenitor Cell Expansion, Differentiation, and Hair Follicle Regression by miR-22

research Expression Analysis of KAP9.2 and Hoxc13 Genes During Different Cashmere Growth Stages by qRT-PCR Method

research Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation

research A Homozygous Frameshift Mutation in the HOXC13 Gene Underlies Pure Hair and Nail Ectodermal Dysplasia in a Syrian Family

research Loss-Of-Function Mutations In HOXC13 Cause Pure Hair And Nail Ectodermal Dysplasia

research Hoxc13 And The Development Of Hair Follicle

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

research Krtap16: Characterization of a New Hair Keratin-Associated Protein Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13

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