Hoxc13 And The Development Of Hair Follicle

August 2010 in “ Hereditas (Beijing) ”

Jianghong Wu, Z.W. Yan, sile Hu, Wenguang Zhang, Jinquan Li

Hoxc13 hair follicle keratin keratin-associated proteins Hox gene family

TLDR Hoxc13 is essential for hair growth and follicle development.

The study reviewed the role of the Hoxc13 gene in hair follicle development. Hoxc13 was found to be crucial for the proper formation and differentiation of hair follicles. The research highlighted that mutations or dysregulation in Hoxc13 could lead to hair growth disorders, emphasizing its importance in maintaining normal hair follicle function. The findings contributed to a better understanding of the genetic factors involved in hair development and potential targets for addressing hair-related abnormalities.

View this study on chinagene.cn →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

65 citations , July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

The gene Foxq1, controlled by Hoxc13, is crucial for hair follicle differentiation.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Krtap16: Characterization of a New Hair Keratin-Associated Protein Gene Complex on Mouse Chromosome 16 and Evidence for Regulation by Hoxc13

47 citations , September 2004 in “Journal of Biological Chemistry”

Hoxc13 regulates specific hair protein genes on mouse chromosome 16.

research Structure and Expression of the Ovine Hoxc-13 Gene

12 citations , December 2003 in “Gene”

The ovine Hoxc-13 gene is crucial for hair formation and may have other skin functions.

research Hoxc13 Mutant Mice Lack External Hair

245 citations , January 1998 in “Genes & Development”

Hoxc13 gene is essential for hair, nail, and papilla development.

Related Research

7 / 7 results

The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

research The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

16 citations , December 2019 in “Animals”

Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

research The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice

73 citations , May 2009 in “Proceedings of the National Academy of Sciences”

Disrupting the Sox21 gene in mice causes hair loss and regrowth cycles.

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

More research is needed to understand how hair keratins work and their role in hair disorders.

research Hair Follicle Differentiation And Regulation

199 citations , January 2004 in “The International Journal of Developmental Biology”

Hair follicle growth and development are controlled by specific genes and molecular signals.

research Substance P Prolongs Human Hair Growth In Vitro

8 citations , September 2003 in “Journal of dermatological science”

Substance P helps hair grow longer and faster.

research Study of the Keratinization Process in Human Hair Follicle by X-Ray Microdiffraction

28 citations , July 2000 in “PubMed”

Hair structure forms the same way inside and outside the body.

research Synthesis and Cross-Linking in the Structure and Growth of Hair Keratins

6 citations , October 1988 in “Clinics in Dermatology”

The molecular details of hair growth are not well understood.