Identification of N6-Methyladenosine-Related Factors and the Prediction of the Regulatory Mechanism of Hair Follicle Development in Rex and Hycole Rabbits

This study investigated the role of N6-methyladenosine (m6A) in hair follicle development in Rex and Hycole rabbits, finding that m6A modifications significantly influence hair length, density, and skin thickness. Researchers identified five differential methylases, 20 genes, and 24 signaling pathways related to hair growth, with notable differences in IGF1 and EGFR gene expression. The findings suggest that m6A plays a crucial role in hair follicle development, offering insights for improving animal fur quality and addressing human baldness.