Recent Progress in the Effect of Ferroptosis of Hepatic Stellate Cells on the Development of Liver Fibrosis

Liver fibrosis (LF) is a key process in the progression of chronic liver diseases to cirrhosis and liver cancer, regulated by various cytokines and signaling pathways. Ferroptosis, a type of cell death caused by iron-dependent oxidative damage, has been found to be closely related to LF. Hepatic stellate cells (HSCs), which secrete the extracellular matrix, play a significant role in LF development. Targeting HSC ferroptosis is crucial for treating LF. This review highlights the importance of inducing HSC ferroptosis to manage LF and provides insights into current knowledge and future research directions in this area.