Effect of Sun Exposure-Induced Ferroptosis Mechanisms on Pathology and Potential Biological Processes of Primary Melanoma by Microarray Data Analysis

The study investigated the role of UV exposure-induced ferroptosis in the development of skin cutaneous melanoma (SKCM) using gene expression data. Researchers identified 14 common differentially expressed genes (DEGs) and highlighted seven DEGs, including PSMB4 and CDKN2A, as potential biomarkers for SKCM diagnosis. The study found that the HIF-1 signaling pathway and angiogenesis were involved in SKCM pathogenesis. It suggested that enhancing CD8+ T cell function to induce ferroptosis in tumor cells could be an effective therapeutic strategy. The findings provided insights into potential immunotherapy targets for SKCM treatment through ferroptosis mechanisms.