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Glossaryp16 (CDKN2A)

inhibits cell division by regulating cyclin-dependent kinases

p16, also known as CDKN2A, is a protein that acts as a tumor suppressor by regulating the cell cycle. It inhibits cyclin-dependent kinases (CDKs), which are enzymes that promote cell division, thereby preventing uncontrolled cell growth that can lead to cancer.

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research Genome-Wide Differential Expression Profiles in Nevus Sebaceous Revealed Low Expression of CDKN2AIP and Construction of a ceRNA Network

March 2022 in “Clinical Cosmetic and Investigational Dermatology”

CDKN2AIP gene is less active in nevus sebaceous, affecting related RNA networks.

research Effect of Sun Exposure-Induced Ferroptosis Mechanisms on Pathology and Potential Biological Processes of Primary Melanoma by Microarray Data Analysis

12 citations , September 2022 in “Frontiers in Genetics”

Enhancing CD8+ T cell function to induce ferroptosis in tumor cells may help treat skin melanoma.

research Keratinocyte Cytokine Networks Associated With Human Melanocytic Nevus Development

5 citations , September 2018 in “Journal of Investigative Dermatology”

Keratinocyte cytokines and genetic variations influence the development of moles and skin pigmentation.

research BMI1 Is Required for Melanocyte Stem Cell Maintenance and Hair Pigmentation

4 citations , May 2023 in “Pigment Cell & Melanoma Research”

BMI1 is essential for preventing hair greying and maintaining hair color.

research Main Plenary Sessions: Summaries of Papers

July 2004 in “British Journal of Dermatology”

The document concludes that accurate diagnosis and treatment are crucial in dermatology, and it presents various findings on skin conditions and treatments.

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