Iron Metabolism of the Skin: Recycling Versus Release

The document reviews the metabolism of iron in the skin, emphasizing its role in epidermal processes such as cellular respiration and detoxification. Iron is crucial for both the skin's metabolic activity and the microorganisms on its surface. The study highlights how genes differentially expressed in the epidermis layers regulate iron recycling and prevent its release. Key proteins like HMOX1, SLC40A1, and HEPHL1 are involved in recycling iron from heme in keratinocytes. The review also examines changes in iron metabolism in skin diseases and suggests areas for future research on iron-dependent skin processes.