Iron Metabolism of the Skin: Recycling Versus Release

The review article explores the critical role of iron metabolism in the skin, particularly in epidermal keratinocytes, highlighting its importance in cellular processes like respiration and detoxification. Iron is stored in the epidermis and plays a role in systemic iron regulation, with proteins such as heme oxygenase-1, ferroportin, and transferrin receptor 1 facilitating iron recycling. The skin's iron content varies across layers and conditions, influencing diseases like psoriasis and atopic dermatitis. The review also discusses the role of iron in the skin microbiome and infections, emphasizing the need for further research on iron-dependent skin processes and its impact on systemic iron balance.