Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

    February 2021 in “ Journal of Investigative Dermatology ”
    Elias Bou Samra, Yann Mahe, M. Le Balch … Khalid Bakkar
    Studysummary This study found that specific junctional proteins are significantly downregulated in balding regions of the scalp in men with androgenetic alopecia, suggesting disrupted cell communication may play a role in hair loss.
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    Research cited in this study 5

    1. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    2. Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia Science Translational Medicine · 2012
    3. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    4. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    5. Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia Journal of The American Academy of Dermatology · 1993