CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner

    January 2024 in “ Animals ”
    Qi Zhang, Yixing Fan, Man Bai … Wenlin Bai
    Studysummary In this study, researchers found that circERCC6, a circular RNA identified in cashmere goat hair follicles, helps activate secondary hair follicle stem cells, with its role dependent on specific m6A modifications that interact with miR-412-3p to regulate BNC2 expression.
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    Research cited in this study 11

    1. N6-Methyladenosine Modification of circRNA-ZNF638 Contributes to the Induced Activation of SHF Stem Cells Through miR-361-5p/Wnt5a Axis in Cashmere Goats Animal Bioscience · 2022
    2. Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles Czech Journal of Animal Science · 2022
    3. CircRNA-0100 Positively Regulates the Differentiation of Cashmere Goat SHF-SCs into Hair Follicle Lineage via Sequestering miR-153-3p to Heighten the KLF5 Expression Archives animal breeding/Archiv für Tierzucht · 2022
    4. CircRNA-1926 Promotes Differentiation of Goat SHF Stem Cells into Hair Follicle Lineage by miR-148a/b-3p/CDK19 Axis Animals · 2020
    5. Exosomal MicroRNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation International journal of biological sciences · 2019
    6. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    7. MiR-339-5p Negatively Regulates Loureirin A-Induced Hair Follicle Stem Cell Differentiation by Targeting DLX5 Molecular Medicine Reports · 2018
    8. Integrated Analysis of Coding Genes and Non-Coding RNAs During Hair Follicle Cycle of Cashmere Goat (Capra Hircus) BMC Genomics · 2017
    9. Comparative Transcriptome Analysis Reveals That a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats PLoS ONE · 2016
    10. The Importance of Basonuclin 2 in Adult Mice and Its Relation to Basonuclin 1 Mechanisms of Development · 2016
    11. Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion Stem Cells · 2006