CircERCC6 Positively Regulates the Induced Activation of SHF Stem Cells in Cashmere Goats via the miR-412-3p/BNC2 Axis in an m6A-Dependent Manner

January 2024 in “ Animals ”

Qi Zhang, Yixing Fan, Man Bai, Ying Zhu, Zeying Wang, Jincheng Shen, Ru Xu, Wenxin Zheng, Wenlin Bai

circERCC6 secondary hair follicle SHF stem cells miR-412-3p BNC2 m6A modifications anagen phase mRNA knockdown experiments dual-luciferase reporter assays hair follicle stem cells microRNA messenger RNA gene knockdown reporter assay

TLDR Circular RNA ERCC6 helps activate stem cells important for cashmere goat hair growth by interacting with specific molecules in an m6A modification-dependent way.

The study reveals that circERCC6 plays a crucial role in activating secondary hair follicle (SHF) stem cells in cashmere goats through the miR-412-3p/BNC2 pathway, with m6A modifications being essential for this process. High circERCC6 expression during the anagen phase and its interaction with miR-412-3p to upregulate BNC2 mRNA were confirmed through knockdown experiments and dual-luciferase reporter assays. These findings provide insights into the molecular mechanisms of SHF regeneration and cashmere fiber growth, suggesting that targeting circERCC6 could enhance cashmere yield and quality.

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