Role of the Soluble Epoxide Hydrolase in Hair Follicle Stem Cell Homeostasis and Hair Growth

The study investigated the role of the enzyme soluble epoxide hydrolase (sEH) in hair follicle stem cell homeostasis and hair growth. It found that sEH is present in hair follicle stem cells and hair matrix cells, and its activity is required for optimal cell proliferation. The research showed that hair follicle elongation and the transition from telogen to anagen were significantly affected in mice lacking sEH. The study also found that hair matrix cell proliferation was greater and hair outgrowth was faster in mice lacking sEH or treated with an sEH inhibitor. The absence of sEH influenced levels of the prostaglandin F2 receptor, promoting PGF2α signaling, which is associated with hair follicle development and has shown promise in treating hair loss. The study suggests that inhibiting sEH could be a therapeutic option for hair loss treatment. The study involved multiple groups of mice, with group sizes ranging from 4 to 10 mice.