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    Corticotropin-Releasing Hormone Inhibits Autophagy by Suppressing PTEN to Promote Apoptosis in Dermal Papilla Cells

    April 2025 in “ Annals of Medicine ”
    Wenzi Liang, Xiuwen Chen, Na Ni … Keng Huang
    Studysummary This study suggests that the key mechanism of stress-related hair loss involves CRH-induced PTEN loss, which reduces autophagy and increases apoptosis in dermal papilla cells, highlighting potential therapeutic targets like PTEN activation or autophagy enhancement.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 9

    1. A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics ACS Biomaterials Science & Engineering · 2024
    2. Expression of Concern: Dermal Papilla Cell-Secreted Biglycan Regulates Hair Follicle Phase Transition and Regeneration by Activating Wnt/β-Catenin Experimental Dermatology · 2023
    3. Understanding Causes of Hair Loss in Women Dermatologic Clinics · 2021
    4. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    5. Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration Journal of Advanced Research · 2020
    6. The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells BMC Molecular and Cell Biology · 2020
    7. Cross-Sectional Quality of Life Assessment in Patients with Androgenetic Alopecia Dermatologic Therapy · 2020
    8. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    9. Corticotropin-Releasing Hormone: An Autocrine Hormone That Promotes Lipogenesis in Human Sebocytes Proceedings of the National Academy of Sciences · 2002