TLDR CRH can cause hair loss by promoting cell death in hair growth cells.
The study explores the role of corticotropin-releasing hormone (CRH) in stress-related hair loss, focusing on its impact on dermal papilla cells (DPCs). CRH downregulates PTEN, suppressing autophagy and promoting apoptosis in DPCs, which are essential for hair growth. This is mediated through the PI3K/AKT/mTOR pathway. The research, using a chronic unpredictable mild stress mouse model, suggests that overexpression of PTEN or using rapamycin to inhibit this pathway can enhance autophagy and reduce apoptosis, offering potential therapeutic strategies for stress-induced hair loss. The study underscores the significance of PTEN and autophagy in managing stress-related alopecia.
July 2024 in “ACS Biomaterials Science & Engineering” Nanoencapsulated antibiotics are more effective in treating hair follicle infections than free antibiotics.
4 citations,
May 2021 in “Dermatologic Clinics” The conclusion is that hair loss in women is caused by a mix of hormonal, environmental, and genetic factors, and treatments should target these various causes.
77 citations,
March 2021 in “Nature” Stress hormone corticosterone blocks a growth factor to slow down hair stem cell activity and hair growth.
30 citations,
November 2020 in “Journal of Advanced Research” Conditioned medium from keratinocytes can improve hair growth potential in cultured dermal papilla cells.
9 citations,
June 2020 in “BMC Molecular and Cell Biology” Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.
8 citations,
June 2020 in “Dermatologic Therapy” Hair loss lowers quality of life, causing embarrassment, frustration, and sexual rejection.
42 citations,
March 2018 in “PLOS Biology” Autophagy is important for human hair growth and health.
May 2024 in “Clinical Cosmetic and Investigational Dermatology” Manipulating cell cleanup processes could help treat hair loss.
January 2025 in “Applied Sciences” Sulforaphane from broccoli may help treat certain cancers, hormone issues, and hair loss.
June 2025 in “Clinical Cosmetic and Investigational Dermatology” Gray hair can potentially be managed or reversed with treatments that boost melanin production and address nutritional deficiencies.
97 citations,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
47 citations,
February 2015 in “European Journal of Clinical Investigation” The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.