A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics
July 2024
in “
ACS Biomaterials Science & Engineering
”
3D printed model human hair follicles antibiotic nanocarriers follicular infections collagen matrix 3D printed scaffold fluorescent nanoparticles rifampicin-loaded lipid nanocapsules free rifampicin nanoencapsulated form bacterial reduction follicle microenvironment nanocarriers targeted therapy 3D model hair follicles antibiotic carriers infections collagen scaffold nanoparticles rifampicin capsules rifampicin encapsulated antibiotics bacteria reduction microenvironment carriers targeted treatment
TLDR Nanoencapsulated antibiotics are more effective in treating hair follicle infections than free antibiotics.
The study developed a novel 3D printed model of infected human hair follicles to test the targeted delivery of nanoantibiotics. Using a collagen matrix within a 3D printed polycaprolactone scaffold, the model better mimicked in vivo conditions compared to traditional floating cultures. Infected with Staphylococcus aureus and treated with rifampicin-loaded lipid nanocapsules (LNCs), the model showed significant reductions in bacterial colony-forming units (CFU) and deeper follicular penetration of nanoparticles. This approach could enhance the understanding and treatment of hair follicle infections and related diseases, suggesting the model's potential for more effective drug delivery studies.
