A Novel 3D Printed Model of Infected Human Hair Follicles to Demonstrate Targeted Delivery of Nanoantibiotics

    July 2024 in “ ACS Biomaterials Science & Engineering ”
    Samy Aliyazdi, Sarah Frisch, Tobias Neu, Barbara Veldung, Pankaj Karande, Ulrich F. Schaefer, Brigitta Loretz, Thomas Vogt, Claus‐Michael Lehr
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    TLDR Nanoencapsulated antibiotics are more effective in treating hair follicle infections than free antibiotics.
    The study developed a novel 3D printed model of infected human hair follicles to test the targeted delivery of nanoantibiotics. Using a collagen matrix within a 3D printed polycaprolactone scaffold, the model better mimicked in vivo conditions compared to traditional floating cultures. Infected with Staphylococcus aureus and treated with rifampicin-loaded lipid nanocapsules (LNCs), the model showed significant reductions in bacterial colony-forming units (CFU) and deeper follicular penetration of nanoparticles. This approach could enhance the understanding and treatment of hair follicle infections and related diseases, suggesting the model's potential for more effective drug delivery studies.
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