Hair Eruption Initiates and Commensal Skin Microbiota Aggravate Adverse Events of Anti-EGFR Therapy

    December 2019 in “ Science Translational Medicine ”
    Jörg Klufa, Thomas Bauer, Buck Hanson … Maria Sibilia
    Studysummary This study found that EGFR-targeted cancer therapy can cause skin toxicities by disrupting epidermal signaling, allowing microbiota invasion and inflammation, but identified a potential treatment approach using FGF7 or SOS expression to restore barrier integrity.
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    Research cited in this study 2

    1. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    2. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004

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