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Glossary EGFR Signaling

EGFR signaling refers to the pathway activated by the epidermal growth factor receptor (EGFR), a cell surface protein that plays a crucial role in cell proliferation, differentiation, and survival. In the context of hair biology, EGFR signaling is significant as it influences hair follicle development and cycling, particularly in the anagen (growth) phase. Dysregulation of this pathway can contribute to hair loss conditions, such as androgenetic alopecia, by affecting the health and function of hair follicles. Key distinguishing characteristics of EGFR signaling include its involvement in various cellular processes and its potential as a therapeutic target for hair restoration treatments.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

This study found that epidermal growth factor significantly enhances the proliferation of hair follicle-derived mesenchymal stem cells through the EGFR/ERK and AKT pathways, without involving the STAT3 pathway.

research 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

This study developed an Asian human sebocyte cell line from breast skin tissue that can be used for sebaceous gland biology investigations, showing that Y27632 may promote cell growth through EGFR-CRAF-MEK-ERK and AKT pathways.

research Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

41 citations , December 2019 in “Science Translational Medicine”

This study found that EGFR-targeted cancer therapy can cause skin toxicities by disrupting epidermal signaling, allowing microbiota invasion and inflammation, but identified a potential treatment approach using FGF7 or SOS expression to restore barrier integrity.

research Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways

3 citations , September 2024 in “International Journal of Molecular Sciences”

This review examines how mathematical modeling of the MAPK pathway, enhanced by single-cell proteomic data, improves understanding of regulatory mechanisms, predicts system behavior, and guides experimental research, emphasizing recent developments in modeling and inference.

research Epimorphin and Epithelial Morphogenesis

January 2007

This article discusses the role of epimorphin as a key morphoregulator for various epithelial cells in tubulogenesis and reports no experimental results on its signaling pathways.

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