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    Did you mean EGFR Signaling?
    Glossary EGFR Signaling

    EGFR signaling refers to the pathway activated by the epidermal growth factor receptor (EGFR), a cell surface protein that plays a crucial role in cell proliferation, differentiation, and survival. In the context of hair biology, EGFR signaling is significant as it influences hair follicle development and cycling, particularly in the anagen (growth) phase. Dysregulation of this pathway can contribute to hair loss conditions, such as androgenetic alopecia, by affecting the health and function of hair follicles. Key distinguishing characteristics of EGFR signaling include its involvement in various cellular processes and its potential as a therapeutic target for hair restoration treatments.

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    1. Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16 Stem Cells and Development · 2016 · 83 citations
    2. 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line Journal of Investigative Dermatology · 2019
    3. Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy Science Translational Medicine · 2019 · 41 citations
    4. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    5. Epimorphin and Epithelial Morphogenesis 2007
    6. Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis Frontiers in genetics · 2019 · 6 citations
    7. Basal cell carcinoma — molecular biology and potential new therapies Journal of Clinical Investigation · 2012 · 146 citations
    8. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    9. 329 Mechanisms of Cutaneous Adverse Events during Targeted Cancer Therapy 2022
    10. 546 Epidermal growth factor receptor as a key regulator of the immune privilege Journal of Investigative Dermatology · 2022
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