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research Hair Depigmentation Is a Biological Readout for Pharmacological Inhibition of KIT in Mice and Humans

73 citations , October 2003 in “Journal of Pharmacology and Experimental Therapeutics”

This study found that hair depigmentation in mice and humans can be a dynamic indicator of KIT inhibition by the drug SU11248, correlating with treatment periods.

research Therapeutic modulation of KIT ligand in melanocytic disorders with implications for mast cell diseases

4 citations , May 2024 in “Experimental Dermatology”

This study reviews the role of the KIT ligand and receptor pathway in managing melanocyte and mast cell-related skin diseases, examining how its regulation can lead to potential therapies for conditions like vitiligo, melanoma, and mastocytosis. Results are not reported.

research Classic versus non‐classic: A survival Kit for life in the skin

2 citations , September 2009 in “Pigment Cell & Melanoma Research”

This study found that non-cutaneous melanocytes in mice are less sensitive to Kit signaling compared to cutaneous melanocytes, showing dependence on ET3 and HGF signaling.

research Receptor tyrosine kinase Kit action in skin melanocytes: is it exclusively cell autonomous?

1 citations , August 2015 in “Experimental Dermatology”

This review discusses the roles of KIT and mast cells in skin physiology and pathology using different genetic models and reports no new clinical results; the authors suggest further exploration of KIT deficiency.

Casein Kinase 1 Inhibition in Keratinocytes Enhances the Migration of Melanocyte Precursors in the Hair Follicle via KitL/c-Kit Signaling Pathway

research 1339 Casein kinase 1 inhibition in keratinocytes enhances the migration of melanocyte precursors in the hair follicle via KitL/c-Kit signaling pathway

April 2023 in “Journal of Investigative Dermatology”

In this study, topical inhibition of casein kinase 1 in mice was found to enhance melanocyte precursor migration and eumelanin production, suggesting potential applications for treating vitiligo and graying hair through KitL/c-Kit signaling pathway activation.

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Community Join

5 / 207 results

community 30M ~3 month, everything and the kitchen sink

in Progress Pictures 229 upvotes 1 year ago

A 30-year-old male shared his 3-month progress using Minoxidil topical, Finasteride oral, and Dutasteride, along with microneedling, keto shampoo, and rosemary oil for hair regrowth. He reported significant improvement without side effects and plans to continue the regimen.

community 21M, threw in the whole kitchen sink yet still shedding like a dog

14 upvotes 4 years ago

A user has been using finasteride, minoxidil, RU58841, dutasteride, saw palmetto, and pumpkin seed oil but continues to experience significant hair shedding. They are seeking advice on what to do next.

community Male 23 kya topical minoxidil 18 mahine tak istemaal karne ke baad result nahi mila to mujhe oral minoxidil istemaal karna chahiye agar karna chahiye to kitna mg se chaalu kare

3 weeks ago

A user is considering switching from topical to oral minoxidil after 18 months without results, with suggestions to start at 1.25 mg twice daily. Another user shared success with 0.5 mg finasteride nightly and 1.25 mg minoxidil in the morning, suggesting adjusting doses based on results.

community 34M from India, Hair regrowth progress photos

283 upvotes 3 months ago

A 34-year-old from India shared hair regrowth progress using a treatment kit from Traya, which included minoxidil, finasteride, ayurvedic supplements, oil, and shampoo. The user improved diet, fixed vitamin deficiencies, and adjusted lifestyle habits, attributing most progress to minoxidil and finasteride.

community Min + Fin DIY with a cat, what can I use instead?

10 months ago

The user is concerned about the toxicity of a homemade topical solution of minoxidil and finasteride to their new kitten and is considering replacing minoxidil with stemoxydine. Other users suggest using oral treatments, keeping the solution away from the cat, and ensuring proper hygiene.

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