Integration Analysis of Transcriptome Sequencing and Whole-Genome Resequencing Reveals Wool Quality-Associated Key Genes in Zhexi Angora Rabbits

December 2024 in “ Veterinary Sciences ”

Bohao Zhao, Yongqi Yu, Shaoning Sun, Jiawei Cai, Zhiyuan Bao, Yang Chen, Xinsheng Wu

hair follicle development FRZB TRIB3 ACE2 TLR2 Wnt pathway TGF-β pathway JAK-STAT pathway hair follicle Wnt TGF-beta JAK-STAT

TLDR Key genes and pathways improve wool quality in Zhexi Angora rabbits.

This study on Zhexi Angora rabbits used transcriptome sequencing and whole-genome resequencing to explore the genetic factors affecting wool quality. Researchers analyzed 12 rabbits, identifying 182 differentially expressed genes, with 138 upregulated and 44 downregulated in fine-wool rabbits. Key genes such as FRZB, TRIB3, ACE2, and TLR2 were linked to hair follicle development, and pathways like Wnt, TGF-β, and JAK-STAT were enriched. Fine-wool rabbits exhibited higher hair follicle density and finer wool fibers. The study's findings offer valuable insights for molecular breeding programs aimed at enhancing wool quality in Angora rabbits.

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