Activation of the Integrated Stress Response in Human Hair Follicles

    June 2024 in “ PLoS ONE ”
    Derek Pye, Rachel Scholey, Seng Kuong Anakin Ung … Talveen S. Purba
    Studysummary This study found that inhibiting the Mitochondrial Pyruvate Carrier in human scalp hair follicles caused metabolic stress that halted cell proliferation and disrupted key signaling pathways, with these effects partially reversed by an integrated stress response inhibitor.
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    Research cited in this study 20

    1. Human Hair Follicles Operate an Internal Cori Cycle and Modulate Their Growth via Glycogen Phosphorylase Scientific Reports · 2021
    2. XMU-MP-1 Induces Growth Arrest in a Model Human Mini-Organ and Antagonizes Cell Cycle-Dependent Paclitaxel Cytotoxicity Cell division · 2020
    3. CDK4/6 Inhibition Mitigates Stem Cell Damage in a Novel Model for Taxane-Induced Alopecia EMBO Molecular Medicine · 2019
    4. Deciphering the Molecular Morphology of the Human Hair Cycle: Wnt Signalling During the Telogen–Anagen Transformation British Journal of Dermatology · 2019
    5. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    6. Divergent Proliferation Patterns of Distinct Human Hair Follicle Epithelial Progenitor Niches In Situ and Their Differential Responsiveness to Prostaglandin D2 Scientific Reports · 2017
    7. Lactate Dehydrogenase Activity Drives Hair Follicle Stem Cell Activation Nature cell biology · 2017
    8. Characterization of Cell Cycle Arrest and Terminal Differentiation in a Maximally Proliferative Human Epithelial Tissue: Lessons from the Human Hair Follicle Matrix European Journal of Cell Biology · 2017
    9. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    10. A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle Experimental Dermatology · 2016
    11. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    12. Mapping the Expression of Epithelial Hair Follicle Stem Cell-Related Transcription Factors LHX2 and SOX9 in the Human Hair Follicle Experimental Dermatology · 2015
    13. Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges BioEssays · 2014
    14. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Journal of Cell Science · 2013
    15. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    16. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    17. Pathobiology of Chemotherapy-Induced Hair Loss The Lancet Oncology · 2013
    18. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    19. The Pathogenesis of Primary Cicatricial Alopecias The American Journal of Pathology · 2010
    20. The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function Cytokine & Growth Factor Reviews · 2008

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
    3. Putting the Human Hair Follicle Cycle on the Map Journal of Investigative Dermatology · 2016
    4. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
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