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Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

research Inhibition of the Mitochondrial Pyruvate Carrier Promotes ATF4-Dependent Stress Responsive Metabolic Rewiring and Cell Cycle Arrest in the Human Hair Follicle

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking a key energy pathway in human hair follicles can trigger stress responses that stop cell growth.

research Activation of the Integrated Stress Response in Human Hair Follicles

June 2024 in “PLoS ONE”

Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.

research Impact of a Stimulating Cream Shampoo Treatment on the Penetration of Minoxidil Through Hair Follicles

April 2016 in “Journal of Investigative Dermatology”

Using a stimulating cream shampoo before applying Minoxidil helps it penetrate hair follicles better, enhancing its hair growth-promoting effect.

research Visualization of Sweat Suppression Following Botulinum Toxin A by Soluble Microneedle Arrays

April 2016 in “Journal of Investigative Dermatology”

Microneedle arrays deliver botulinum toxin effectively for sweat suppression, similar to injections.

Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

April 2016 in “Journal of Investigative Dermatology”

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

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community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 44 upvotes 3 months ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

in Research/Science 206 upvotes 4 months ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.