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This study found that novel MPC inhibitor analogues with specific chemical modifications promoted significant hair growth in shaved mice when applied topically.

This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.

This study found that inhibiting the Mitochondrial Pyruvate Carrier in human hair follicles ex vivo activated the integrated stress response, affecting cell proliferation and metabolism.

This study found that glycolytic metabolism and lactate production are crucial for hair follicle stem cell activation, and manipulating these processes can stimulate the hair cycle.

In this study, researchers observed that quiescent mouse embryonic fibroblasts showed reduced glycolysis but increased TCA cycle flux and mitochondrial respiration, with these changes linked to metabolic reprogramming involving yes-associated protein inhibition and malate cycle modulation, which supports extracellular matrix protein synthesis.