The FRZB Gene Regulates Hair Follicle Development in Rabbits via the Wnt/β-Catenin Signaling Pathway

September 2023 in “ World Rabbit Science ”

Fan Wang, Xiyu Zhang, Yingying Dai, Bohao Zhao, Xinsheng Wu, Yang Chen

FRZB gene hair follicle development Wnt/β-catenin signaling pathway SFRP2 BMP4 WNT2 LEF1 CCND1 DKK1 TCF7 dermal papilla cells apoptosis proliferation Wnt signaling pathway β-catenin signaling pathway hair growth cell death cell growth

Studysummary In this study using Angora rabbits, researchers found that the FRZB gene inhibits hair follicle development by modulating the Wnt/β-catenin signaling pathway, affecting the expression of various genes related to this pathway and altering cell proliferation and apoptosis. Our plain-language summary of this paper — not a Tressless recommendation.

The study on Angora rabbits reveals that the FRZB gene inhibits hair follicle development by regulating the Wnt/β-catenin signaling pathway. Overexpression of FRZB in rabbit dermal papilla cells suppresses SFRP2, BMP4, and WNT2 genes while increasing LEF1, CCND1, DKK1, and TCF7 genes. The luciferase reporter system confirmed that FRZB reduces Wnt activity, leading to increased apoptosis and decreased cell proliferation in dermal papilla cells.

View this study on polipapers.upv.es →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research LncRNA H19 Overexpression Activates Wnt Signaling to Maintain the Hair Follicle Regeneration Potential of Dermal Papilla Cells

12 citations , August 2020 in “Frontiers in Genetics”

This study suggests that the long noncoding RNA H19 helps dermal papilla cells maintain their hair follicle-inducing ability by activating the Wnt signaling pathway, potentially offering a therapeutic target for androgenetic alopecia.

research MiR-218-5p Regulates Skin and Hair Follicle Development Through Wnt/β-Catenin Signaling Pathway by Targeting SFRP2

54 citations , April 2019 in “Journal of cellular physiology”

In this study, miR-218-5p was found to enhance hair shaft growth and positively regulate the Wnt signaling pathway by targeting SFRP2 during skin and hair follicle development.

research Gene Expression Profiling Analysis Reveals Fur Development in Rex Rabbits (Oryctolagus Cuniculus)

23 citations , August 2017 in “Genome”

This study identified several genes and signaling pathways, such as Wnt and MAPK, involved in fur development in Chinchilla rex rabbits, providing insights into skin and hair follicle growth.

research Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , July 2012 in “Journal of Investigative Dermatology”

In this study, researchers showed that Wnt ligands secreted by hair follicle epithelium are crucial for hair follicle regeneration and may be significant for treating hair disorders like alopecia.

research Normal Fur Development and Sebum Production Depend on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands

40 citations , June 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

This study revealed that deficiency in the enzyme FA2H in mice affected sebaceous gland function, altered sebum composition, and caused cycling alopecia, highlighting FA2H's role in hair follicle homeostasis.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

This article discusses the hair follicle's regenerative cycles and the molecular mechanisms influencing them, emphasizing the need for therapeutic targeting of the "hair cycle clock" to manage hair growth disorders, without reporting new research findings.

research 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

This study found that topical estradiol inhibits hair growth in mice by preventing the hair follicle's transition from resting to growth phase, a process reversible with an estrogen receptor antagonist.