The study investigated the role of the FRZB gene in hair follicle development in Angora rabbits through the Wnt/β-catenin signaling pathway. Using cell culture, transfection, apoptosis, and proliferation assays, it was found that overexpression of FRZB inhibited SFRP2, BMP4, and WNT2 genes while up-regulating LEF1, CCND1, DKK1, and TCF7 genes. The luciferase reporter system showed that pcDNA3.1-FRZB inhibits Wnt activity, promoting apoptosis and inhibiting proliferation in dermal papilla cells. The conclusion is that FRZB inhibits hair follicle development by regulating the Wnt/β-catenin signaling pathway.
12 citations,
August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
54 citations,
April 2019 in “Journal of cellular physiology” miR-218-5p helps skin and hair growth by targeting SFRP2 and activating a specific signaling pathway.
170 citations,
January 2013 in “Journal of Investigative Dermatology” Wnt ligands are crucial for hair growth and repair.
40 citations,
July 2011 in “Journal of biological chemistry/The Journal of biological chemistry” FA2H is essential for normal fur and sebum production in mice.
224 citations,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
71 citations,
February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” Estradiol stops hair growth in mice, but an antagonist can reverse this effect.
12 citations,
August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
