Stat3 Partly Inhibits Cell Proliferation Via Direct Negative Regulation of FST Gene Expression

    June 2021 in “ Frontiers in genetics ”
    Haidong Xu, Guangwei Ma, Fang Mu … Ning Wang
    Studysummary This study found that STAT3 directly inhibited the activity of the sheep FST gene promoter, consequently reducing cell proliferation and promoting a better understanding of hair follicle development mechanisms.
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    Research cited in this study 18

    1. IL-36α Promoted Wound-Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation Frontiers in Cell and Developmental Biology · 2020
    2. Embryonic-Like Regenerative Phenomenon: Wound-Induced Hair Follicle Neogenesis Regenerative Medicine · 2018
    3. Polymorphisms of FST Gene and Their Association with Wool Quality Traits in Chinese Merino Sheep PloS one · 2017
    4. Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2016
    5. Protopanaxatriol Type Ginsenoside Re Promotes Cyclic Growth of Hair Follicles via Inhibiting Transforming Growth Factor β Signaling Cascades Biochemical and Biophysical Research Communications · 2016
    6. dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration Cell Stem Cell · 2015
    7. Constitutive Stat3 Activation Alters Behavior of Hair Follicle Stem and Progenitor Cell Populations Molecular Carcinogenesis · 2013
    8. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    9. Hydroxyl Radical Mediates Cisplatin-Induced Apoptosis in Human Hair Follicle Dermal Papilla Cells and Keratinocytes Through Bcl-2-Dependent Mechanism APOPTOSIS · 2011
    10. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    11. The Role of Activins and Follistatins in Skin and Hair Follicle Development and Function Cytokine & Growth Factor Reviews · 2008
    12. GLI2-Specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells Journal of biological chemistry/˜The œJournal of biological chemistry · 2008
    13. Impact of Stat3 Activation Upon Skin Biology: A Dichotomy of Its Role Between Homeostasis and Diseases Journal of Dermatological Science · 2007
    14. The Hair Cycle Journal of Cell Science · 2006
    15. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    16. Impaired Wound Healing in Transgenic Mice Overexpressing the Activin Antagonist Follistatin in the Epidermis EMBO journal · 2001
    17. Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways Proceedings of the National Academy of Sciences of the United States of America · 2000
    18. Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes Journal of dermatological science · 2000