Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

    October 2007 in “ Journal of Investigative Dermatology ”
    Marlon R. Schneider, Maria Antsiferova, Laurence Feldmeyer … Sabine Werner
    Studysummary This study found that overexpression of betacellulin in transgenic mice delayed hair follicle morphogenesis and cycling, increased keratinocyte proliferation, and enhanced wound angiogenesis without affecting wound healing strength.
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    Research cited in this study 9

    1. Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes ˜The œAmerican journal of pathology · 2005
    2. Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle Journal of biological chemistry/˜The œJournal of biological chemistry · 2003
    3. Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin The FASEB Journal · 2003
    4. Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing Journal of Burn Care & Rehabilitation · 2002
    5. Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development PubMed · 1997
    6. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995
    7. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993
    8. Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice The EMBO Journal · 1993
    9. Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation Genes & Development · 1991

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