Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

October 2007 in “ Journal of Investigative Dermatology ”

Marlon R. Schneider, Maria Antsiferova, Laurence Feldmeyer, Maik Dahlhoff, Philippe Bugnon, Sybille Hasse, Ralf Paus, Eckhard Wolf, Sabine Werner

Betacellulin BTC keratinocyte proliferation angiogenesis hair follicle morphogenesis hair cycle initiation epidermal homeostasis

TLDR Betacellulin helps blood vessel growth in wounds but delays hair growth.

The study investigated the role of Betacellulin (BTC) in skin biology using transgenic mice overexpressing BTC. It was found that BTC increased keratinocyte proliferation and enhanced angiogenesis at wound sites, but caused a delay in hair follicle morphogenesis and hair cycle initiation. Despite these effects, BTC did not alter keratinocyte differentiation or wound healing rates. The study highlighted BTC's role in regulating epidermal homeostasis, hair follicle development, and wound angiogenesis, suggesting its potential in treating poorly vascularized wounds without oncogenic risks.

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Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

Betacellulin Regulates Hair Follicle Development and Hair Cycle Induction and Enhances Angiogenesis in Wounded Skin

Research cited in this study

research Activin Controls Skin Morphogenesis and Wound Repair Predominantly via Stromal Cells and in a Concentration-Dependent Manner via Keratinocytes

research Epidermal Growth Factor as a Biological Switch in Hair Growth Cycle

research Control of Pelage Hair Follicle Development and Cycling by Complex Interactions Between Follistatin and Activin

research Endogenous Production of Heparin-Binding EGF-Like Growth Factor During Murine Partial-Thickness Burn Wound Healing

research Genetically Null Mice Reveal a Central Role for Epidermal Growth Factor Receptor in the Differentiation of the Hair Follicle and Normal Hair Development

research Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure.

research Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation

research Targeting Expression of Keratinocyte Growth Factor to Keratinocytes Elicits Striking Changes in Epithelial Differentiation in Transgenic Mice

research Transgenic Mice Provide New Insights Into the Role of TGF-Alpha During Epidermal Development and Differentiation

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