Comparative Transcriptome Analysis Reveals That a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats

    October 2016 in “ PLoS ONE ”
    Xiaoyang Ji, Jianxun Wang, Bin Liu, Zhuqing Zheng, Shaoyin Fu, Getinet Mekuriaw Tarekegn, Xue Bai, Yongsheng Bai, Heng Li, Wenguang Zhang
    TLDR The ubiquitin-mediated proteolysis pathway is crucial for hair follicle development in cashmere goats.
    The study conducted a comparative transcriptome analysis on 18 hair follicles from cashmere goats, identifying numerous differentially expressed exons through high-throughput sequencing. It concluded that the ubiquitin-mediated proteolysis pathway (UMPP) played a significant role in differentiating primary and secondary hair follicles in cashmere goats. This research provided valuable insights into the biological study of hair follicles in cashmere goats and potentially other mammals.
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