Comparative Transcriptome Analysis Reveals That a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats

October 2016 in “ PLoS ONE ”

Xiaoyang Ji, Jianxun Wang, Bin Liu, Zhuqing Zheng, Shaoyin Fu, Getinet Mekuriaw Tarekegn, Xue Bai, Yongsheng Bai, Heng Li, Wenguang Zhang

TLDR The ubiquitin-mediated proteolysis pathway is crucial for hair follicle development in cashmere goats.

The study conducted a comparative transcriptome analysis on 18 hair follicles from cashmere goats, identifying numerous differentially expressed exons through high-throughput sequencing. It concluded that the ubiquitin-mediated proteolysis pathway (UMPP) played a significant role in differentiating primary and secondary hair follicles in cashmere goats. This research provided valuable insights into the biological study of hair follicles in cashmere goats and potentially other mammals.

View this study on journals.plos.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat

81 citations , September 2013 in “PLoS ONE”

Primary and secondary hair follicle cells in Cashmere goats have different gene expressions affecting hair growth and size.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations , April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Characterization of BMP2 Gene Expression in Embryonic and Adult Inner Mongolia Cashmere Goat (Capra Hircus) Hair Follicles

18 citations , December 2009 in “Canadian Journal of Animal Science”

The BMP2 gene is more active in the early growth phase of Cashmere goat hair and may affect hair regeneration and textile production.

Related Research

1 / 1 results

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling

65 citations , September 2004 in “The American journal of pathology”

Blocking BMP signaling causes hair loss and disrupts hair growth cycles.

Comparative Transcriptome Analysis Reveals That a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats

Research cited in this study

research Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

research Characterization of BMP2 Gene Expression in Embryonic and Adult Inner Mongolia Cashmere Goat (Capra Hircus) Hair Follicles

research Isolation of a Novel Population of Multipotent Adult Stem Cells from Human Hair Follicles

research Edar Signaling in the Control of Hair Follicle Development

research Molecular Mechanisms Regulating Hair Follicle Development

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

research Splitting Hairs: Molecular Mechanisms of Hair and Feather Development

research Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin

Related Research

research Bone Morphogenetic Protein Signaling Regulates Postnatal Hair Follicle Differentiation and Cycling