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GlossaryGene Expression Analysis (transcriptome analysis)

technique to measure gene activity in different conditions

Gene Expression Analysis is a technique used to study how genes are turned on or off in cells, which helps scientists understand how genes contribute to various biological processes and diseases. By measuring the levels of RNA produced from genes, researchers can determine which genes are active in different tissues or under different conditions, providing insights into functions like hair growth or the mechanisms behind conditions like alopecia.

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Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

research Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

5 citations, September 2021 in “Frontiers in Cell and Developmental Biology”

Dihydrotestosterone treatment on 2D and 3D-cultured skin cells slows down hair growth by affecting certain genes and could be a potential target for hair loss treatment.

research Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair

5 citations, June 2017 in “in Vivo”

Vitamin C deficiency changes gene expression, affecting skin and hair health.

research Transcriptome Analysis of Improved Wool Production in Skin-Specific Transgenic Sheep Overexpressing Ovine β-Catenin

4 citations, January 2019 in “International journal of molecular sciences”

Genetically modified sheep with more β-catenin grew more wool without changing the wool's length or thickness.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

2 citations, August 2020 in “Scientific reports”

Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.

research Transcriptome Analysis to Identify the Downstream Genes of Androgen Receptor in Dermal Papilla Cells

1 citations, January 2022 in “BMC Genomic Data”

The study found that androgen receptors in skin cells mainly affect the focal adhesion pathway and control the caveolin-1 gene, with implications for new treatments for related diseases.

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community Results of Procyanidin B2 in clinical studies

in Treatment 13 upvotes 4 years ago

Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.