Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair

June 2017 in “ in Vivo ”

Koji Wakame, Kenichi Komatsu, Akifumi Nakata, Keisuke Sato, Akira Takaguri, Hirofumi Masutomi, Takayuki Nagashima, Hiroo Uchiyama

SMP30/GNL knockout mice Vitamin C deficiency RNA sequencing differentially expressed genes cell death cytotoxicity hair growth histological examination cell growth hair cycle Vitamin C RNA-seq gene expression histology

TLDR Vitamin C deficiency changes gene expression, affecting skin and hair health.

In 2017, a study was conducted using SMP30/GNL knockout mice to examine the effects of Vitamin C deficiency on skin and hair growth. The mice were divided into two groups: one group was administered Vitamin C (VC(+)) and the other was not (VC(-)). Skin samples were collected at 4 and 8 weeks for RNA sequencing, revealing 1,736 differentially expressed genes between the two groups. The VC(+) group showed increased cell death and cytotoxicity, but also significantly promoted hair growth, as confirmed by histological examination. The study concluded that Vitamin C deficiency affects the expression of genes involved in cell growth and the hair cycle, suggesting that Vitamin C plays a crucial role in maintaining healthy skin and hair.

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Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair

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