Health Benefits and Safety of Red Pigmented Rice (Oryza Sativa L.): In Vitro, Cellular, and In Vivo Activities for Hair Growth Promoting Treatment

November 2022 in “ Cosmetics ”

Natthawut Thitipramote, Supapong Imsonpang, Passanesh Sukphopetch, Prinyaporn Pradmeeteekul, Junniphaphorn Nimkamnerd, Witayapan Nantitanon, Wantida Chaiyana

red pigmented rice Oryza sativa Sang-Yod Mun-Poo 5α-reductase inhibition androgenic alopecia dihydrotestosterone hair matrix cells hair growth C3H mice skin irritation red rice black rice SY MP 5-alpha-reductase inhibition DHT hair cells mice

Studysummary This study observed that SY red pericarp rice extract promotes hair growth, inhibits 5α-reductase, and enhances hair regeneration in mice, with the extract being safe from cytotoxicity and irritation, indicating its potential as a natural hair growth promoter.

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The study "Health Benefits and Safety of Red Pigmented Rice (Oryza sativa L.): In Vitro, Cellular, and In Vivo Activities for Hair Growth Promoting Treatment" found that Thai native red and black pigmented rice extracts, particularly Sang-Yod (SY) and Mun-Poo (MP), have hair growth-promoting properties. The extracts showed in vitro 5α-reductase inhibition, which can help prevent androgenic alopecia by blocking the conversion of testosterone to dihydrotestosterone, a hormone that contributes to hair loss. The extracts also increased the proliferation of human hair matrix cells and promoted extensive hair growth in C3H mice without causing skin irritation. The study concludes that red pigmented rice, especially Sang-Yod rice, could be a potential natural source for hair growth-promoting products.

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