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research Measurement of cortisol in human Hair as a biomarker of systemic exposure

567 citations , October 2007 in “Clinical and investigative medicine”

This study described a new assay for measuring cortisol in hair and found it may serve as a useful biomarker for long-term cortisol exposure, correlating with 24-hour urine cortisol levels in non-obese subjects.

research Emerging Topical and Systemic JAK Inhibitors in Dermatology

277 citations , December 2019 in “Frontiers in Immunology”

This review discusses the immunological basis and development of Janus kinase inhibitors for treating skin diseases and reports no new clinical findings.

research Polymeric nanoparticles‐based topical delivery systems for the treatment of dermatological diseases

263 citations , February 2013 in “Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology”

This review discusses nanoparticle-based topical delivery systems for treating skin diseases and presents no new clinical findings; it emphasizes natural polymer-based nanoparticles and future applications like targeted drug delivery.

research Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells

260 citations , January 2020 in “Nature”

Stress can cause hair to turn gray by depleting stem cells.

research The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults

213 citations , June 2017 in “Rheumatology”

This guideline outlines the management of systemic lupus erythematosus in adults but reports no new clinical findings.

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community Systematic DHT vs Scalp DHT Suppression

3 months ago

Scalp DHT suppression is more effective than systemic suppression, with 0.5 mg finasteride blocking 85-90% of scalp DHT. The discussion seeks further insights on this topic.

community How systematic would topical dutasteride go?

3 upvotes 6 days ago

Topical dutasteride's effectiveness and systemic absorption are debated, with mixed anecdotal evidence on side effects and regrowth. Some users report systemic effects, while others believe the molecules are too large to penetrate the skin.

community Non-systemic hair loss stack, is there any hope?

6 upvotes 2 weeks ago

A 19-year-old is experiencing hair thinning and has tried various doses of oral and topical finasteride but faced psychological and sexual side effects. They are considering topical anti-androgens like KX826, ketoconazole cream, and RU58841 as alternatives, while others suggest clascoterone and topical dutasteride.

community Minimizing systemic DHT reduction with topicals

5 upvotes 3 weeks ago

The conversation discusses minimizing systemic DHT reduction using topical treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and a proprietary carrier for DUT by XYON Health. The focus is on finding effective DHT blockers with minimal systemic absorption.

community 4 years wearing hair systems - what nobody tells you when you start

227 upvotes 6 months ago

Hair systems require frequent maintenance and can be costly, but a DIY approach with bi-weekly changes can help manage these issues. Minoxidil and finasteride were tried but not consistently used due to side effects and personal preferences.

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