Non-systemic hair loss stack, is there any hope?
    8/31/2026

    From the encyclopedia
    Finasteride →

    Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

    Ketoconazole →

    Antifungal, best known as a dandruff shampoo

    RU58841 →

    Experimental topical anti-androgen sold as a research chemical

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💊 Finasteride (oral) 2 years
    💧 Finasteride (topical) 0.01% 2 years
    💧 KX826 / Pyrilutamide (topical)
    💧 Ketoconazole (topical) 2%
    💧 RU58841 (topical)
    the tone is 😞 negative.

    Other terms

    A 19-year-old is experiencing hair thinning and has tried various doses of oral and topical finasteride but faced psychological and sexual side effects. They are considering topical anti-androgens like KX826, ketoconazole cream, and RU58841 as alternatives, while others suggest clascoterone and topical dutasteride.
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