The Role of Androgens in COVID-19

October 2020 in “ Diabetes and Metabolic Syndrome: Clinical Research and Reviews ”

Fatemeh Moradi, Behnaz Enjezab, Akram Ghadiri-Anari

androgens TMPRSS2 SARS-CoV-2 androgen-targeted therapies

TLDR Higher androgen levels might make COVID-19 worse, especially in men.

The document discussed the role of androgens in COVID-19, highlighting that androgens might influence the severity of the disease. It suggested that higher androgen levels could be linked to increased expression of TMPRSS2, a protein that facilitates SARS-CoV-2 entry into cells. This connection could explain why men, who generally have higher androgen levels, experienced more severe COVID-19 outcomes compared to women. The study emphasized the need for further research to explore androgen-targeted therapies as potential treatments for COVID-19.

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