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research Newly Developed Targeted Therapies Against the Androgen Receptor in Triple-Negative Breast Cancer: A Review

49 citations , December 2022 in “Pharmacological Reviews”

This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.

research Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome

October 2023 in “Frontiers in endocrinology”

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

research Molecular Mechanisms Lead to Sex-Specific COVID-19 Prognosis and Targeted Therapies

10 citations , December 2020 in “Frontiers in Medicine”

This review discusses the molecular differences between male and female responses to SARS-CoV-2 infection and highlights the lack of specific guidelines for altering sex-specific COVID-19 prognoses.

research The role of androgens in COVID-19

40 citations , October 2020 in “Diabetes and Metabolic Syndrome: Clinical Research and Reviews”

This review discusses the potential role of androgens in increasing susceptibility to severe COVID-19 complications in men but presents no new clinical findings.

research A Comprehensive Review on Alopecia: Mechanisms, Classification, and Therapeutic Strategies

May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This review explores the complex causes and treatment options for alopecia, emphasizing that current therapies mainly offer symptomatic relief, while new advancements like stem cell approaches and improved drug delivery systems show promise for addressing underlying disease mechanisms.

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Community Join

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community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Grey Market GT20029 and Frequency of Application

in Product 10 upvotes 2 years ago

The conversation is about the potential release of GT20029 on the grey market and concerns about its safety and authenticity. One user advises waiting for the official release by Kintor.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

153 upvotes 6 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

community Average r/bald user complaining

401 upvotes 9 months ago

Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

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Learn

7 / 16 results

learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn TDM-105795

What types of alopecia or hair loss conditions might TDM-105795 be designed to target based on current research? TDM-105795 may target non-scarring alopecia, particularly androgenetic alopecia.

learn Finasteride

Is Finasteride unbeatable or are there equally powerful alternatives? Trials report finasteride as the single medication with the strongest measured effect in male androgenetic alopecia, while dutasteride, minoxidil, topical finasteride, PRP, LLLT and microneedling all have supporting studies and are often reported to work better in combination. Finasteride, dutasteride and oral minoxidil are prescription-only, and several of these uses are off-label.

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