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This review discusses androgen receptor targeting as a potential treatment strategy for triple-negative breast cancer and reports no new experimental outcomes.

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

This review discusses the molecular differences between male and female responses to SARS-CoV-2 infection and highlights the lack of specific guidelines for altering sex-specific COVID-19 prognoses.

This review discusses the potential role of androgens in increasing susceptibility to severe COVID-19 complications in men but presents no new clinical findings.

This review explores the complex causes and treatment options for alopecia, emphasizing that current therapies mainly offer symptomatic relief, while new advancements like stem cell approaches and improved drug delivery systems show promise for addressing underlying disease mechanisms.

This review highlights that alopecia's complex causes include hormonal, genetic, and environmental factors, and discusses traditional and emerging therapies, suggesting a need for multi-targeted, mechanism-based treatments to improve long-term management and efficacy.

This review explores the potential impact of hormonal changes during aging on benign prostate hyperplasia-related urinary symptoms and metabolic syndrome, highlighting the hypothesis of a male PCOS-equivalent but reports no new clinical results.

This study found that patients with androgenetic alopecia had significantly higher COVID-19 severity compared to matched controls, suggesting a potential link between androgen pathways and disease severity. The authors suggest further research to validate this hypothesis and explore antiandrogen treatments for managing COVID-19 severity.

This study examines the genetic underpinnings of chronic dermatological conditions like acne, androgenetic alopecia, and alopecia areata, concluding that a deep understanding of these mechanisms can advance patient-specific treatments and inform cosmetic practices related to skin and hair health.

This study highlights the potential of polymeric micelles in enhancing the targeted delivery and efficacy of treatments for androgenetic alopecia, by offering improved retention on the scalp, extended release, and reduced systemic side effects compared to conventional therapies like minoxidil and finasteride.

This article reviews treatment options for androgenetic alopecia and suggests that therapy should be personalized and targeted at various pathophysiological aspects, but reports no new clinical findings.

This study found that AR/VDR-targeted agonist hormone therapy can inhibit cell viability in HR2-av triple-negative breast cancer cell lines through multiple mechanisms and may enhance the effects of chemotherapy.

This review discusses the role of the androgen receptor in breast cancer diagnosis and treatment, and notes a lack of new research results on its therapeutic potential.

This review highlights the potential of PROTACs to transform cancer treatment by selectively degrading oncogenic proteins, overcoming drug resistance, and reducing toxicity; it also discusses challenges in optimizing these therapies for personalized applications.

This review synthesizes recent research to propose a precision framework for treating androgenetic alopecia and alopecia areata based on genetic insights and pathway biology, highlighting the roles of androgen-receptor signaling, immune dysregulation, and emerging therapies like regenerative medicine and AI-assisted diagnostics.

This review discusses the dual role of testosterone in COVID-19 progression and suggests its importance in understanding the disease's mechanisms, highlighting the need for further targeted research.

This review discusses current and emerging treatments for androgenetic alopecia, covering mechanisms, efficacy, and safety of both androgen-targeted and non-androgen-targeted approaches, but reports no new clinical results.

This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.

This review discusses the latest findings presented at the 4th Intercontinental Meeting of Hair Research Societies, covering advances in hair follicle biology, genetic bases for hair disorders, and potential new therapeutic approaches, but it reports no original study results.

This review summarizes existing knowledge on androgen receptor activity in breast cancer and reports no new clinical findings, with emphasis on therapies targeting androgen signaling in specific BC subtypes.

This study developed a method for designing peptide-based PROTAC drugs using advanced AI models, successfully identifying peptides that bind to specific receptors and incorporating them into a potential transdermal treatment for androgenetic alopecia.

This review discusses the roles of glucocorticoid and sex hormone receptors in the skin and their clinical importance, but reports no new research findings.

This review discusses hormone-related hair disorders and explores potential therapies, including microparticle-based drug delivery systems, without providing new clinical findings.

This study demonstrated that the antiandrogen drug enzalutamide may reduce TMPRSS2 levels in human lung cells and mouse lungs, supporting its potential as a COVID-19 treatment option.

This review highlights that while pharmacotherapy, including biological agents, provides varying but often partial control of hidradenitis suppurativa depending on disease severity, significant challenges and high relapse rates persist, necessitating further research for more effective treatments.

This review discusses causes, diagnostic guidelines, and management strategies for hirsutism, highlighting the need for appropriate evaluations and treatment considerations in different patient populations, but reports no new clinical results.

This research suggests that recent discoveries of signaling pathways in androgenic alopecia may pave the way for targeted therapies, providing potential new treatment options beyond the current FDA-approved drugs, minoxidil and finasteride.

In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.

This study demonstrated that in a mouse model of androgenic alopecia, PLGA-DUT/siAR@DPCM nanoparticles effectively delivered drugs to hair follicles, suppressed androgen-related targets, promoted cell proliferation, and showed significant therapeutic effects with minimal adverse effects, suggesting their potential for clinical application.

This review summarizes research on androgens' roles in female reproductive function, noting their impact on IVF outcomes and the development of PCOS, and highlights the need for mechanism-based therapies.