Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids
January 2016
in “
Evidence-based Complementary and Alternative Medicine
”
Studysummary This study found that rice bran ash extract and orthosilicic acid both increased melanin synthesis and related protein expression in melanocytes, suggesting potential therapeutic use for melanin deficiency.
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The study explored the pigmentation-promoting effects of orthosilicic acid (OSA) and rice bran extract (RBE) on human melanoblasts. It found that melanin levels were 10% higher in cells treated with OSA, RBE, and α-melanocyte-stimulating hormone (MSH) compared to controls. Tyrosinase activity was 10% higher in the OSA and MSH groups and 20% higher in the RBE group. Both OSA and RBE increased the expression of melanogenic markers and enhanced melanin synthesis, with RBE showing greater efficacy than MSH. However, they also induced a 10% increase in lactate dehydrogenase (LDH) activity, indicating cell stress. The study concluded that RBE and OSA could stimulate melanocyte activity and promote pigmentation, with RBE being a potential novel material for enhancing melanin production.
