Effect of Sodium Silicate on Hair Growth in C57BL/6 Mice

    January 2010 in “ Laboratory Animal Research
    Jin-Joo Hue, Bum-Ki Jo, Bong Su Kang, Jun-hyeong Kim, Sang Yoon Nam, Young Won Yun, Jong Soo Kim, Jae-Hwang Jeong, Sang-Hwa Lee, Jun Bae Ahn, Beom Jun Lee
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    TLDR Sodium silicate helped mouse hair grow similarly to a known hair growth treatment.
    In a 2010 study, the effects of sodium silicate on hair growth were examined in C57BL/6 mice. The study compared the application of two concentrations of sodium silicate (50% and 100% Na2SiO3), 5% minoxidil (MXD), and distilled water (DW) over three weeks. Results indicated that sodium silicate, like MXD, promoted hair regrowth compared to DW. MXD increased y-glutamyl transpeptidase activity, while sodium silicate did not significantly affect enzyme activities but did increase epidermal growth factor expression. Neither treatment significantly altered vascular endothelial growth factor levels, but both decreased transforming growth factor-beta1 expression. These findings suggest sodium silicate may be beneficial for treating alopecia or baldness, although the number of mice used in the study was not specified in the summary.
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