Synergistic Effect of Rice Bran Extract and Extremely Low-Frequency Electromagnetic Fields on Dermal Papilla/Melanocytes in Melanogenesis

October 2018 in “ Bioelectromagnetics ”

Soon-Joung Kwon, Yumi Kim, Hyun‐Jun Jang, Young-Kwon Seo

rice bran extract extremely low-frequency electromagnetic fields melanogenesis dermal papilla tyrosinase MITF TRP-1 ET-1 laminin bFGF β-catenin melanin melanocytes RBE EMF

Studysummary This study found that treating a 3D hair dermal papilla model with rice bran extract and electromagnetic fields increased melanogenesis, suggesting potential for vitiligo and white hair therapies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigated the effects of rice bran extract (RBE) and extremely low-frequency electromagnetic fields (EMFs) on melanogenesis in a 3D hair dermal papilla model. The combination of RBE and EMF (RBE/EMF) showed no cell stress and significantly increased tyrosinase activity, MITF, TRP-1, and tyrosinase expression. Additionally, mRNA expression of ET-1, laminin, bFGF, β-catenin, MITF, and tyrosinase was elevated in the RBE/EMF group. Immunostaining confirmed the highest melanin content in this group. These findings suggested that RBE and EMF could be potential treatments for vitiligo and white hair by enhancing melanogenesis in melanocytes.

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Research cited in this study

6 / 6 results

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11 citations , January 2016 in “Evidence-based Complementary and Alternative Medicine”

This study found that rice bran ash extract and orthosilicic acid both increased melanin synthesis and related protein expression in melanocytes, suggesting potential therapeutic use for melanin deficiency.

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314 citations , April 2010 in “Developmental Cell”

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

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24 citations , February 2006 in “Chinese Medical Journal”

This study found that dermal papilla cells cultured in vitro can promote hair follicle regeneration and maintain hair growth, with stronger ET-1 and SCF expression enhancing this regenerative ability.

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34 citations , October 1998 in “PubMed”

This article reviews the role of stem cells and cytokines in hair growth and discusses existing and potential treatments, but it presents no new clinical data.

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85 citations , January 1991 in “Journal of Investigative Dermatology”