Synergistic Effect of Rice Bran Extract and Extremely Low-Frequency Electromagnetic Fields on Dermal Papilla/Melanocytes in Melanogenesis

The study investigated the effects of rice bran extract (RBE) and extremely low-frequency electromagnetic fields (EMFs) on melanogenesis in a 3D hair dermal papilla model. The combination of RBE and EMF (RBE/EMF) showed no cell stress and significantly increased tyrosinase activity, MITF, TRP-1, and tyrosinase expression. Additionally, mRNA expression of ET-1, laminin, bFGF, β-catenin, MITF, and tyrosinase was elevated in the RBE/EMF group. Immunostaining confirmed the highest melanin content in this group. These findings suggested that RBE and EMF could be potential treatments for vitiligo and white hair by enhancing melanogenesis in melanocytes.