A Two-Phase Model of Skin Epidermal Stratification: Lessons from Centrosomes
July 2020
in “
bioRxiv (Cold Spring Harbor Laboratory)
”
skin epidermal stratification cell division orientation basal keratinocyte progenitors centrosomes mitotic spindle mitotic surveillance pathway p53 53BP1 USP28 epidermal differentiation basal transit-amplifying cells suprabasal transit-amplifying cells cell delamination tissue homeostasis hyperproliferation
Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.
Studysummary This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.
Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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