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Research

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research High proliferation and delamination during skin epidermal stratification

51 citations , May 2021 in “Nature Communications”

This study found that ablating centrosomes in developing epidermis alters keratinocyte division without majorly affecting differentiation, suggesting early epidermal development is driven by high proliferation and cell delamination.

research A two-phase model of skin epidermal stratification: lessons from centrosomes

1 citations , July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that centrosome ablation in developing epidermis triggers cell surveillance pathways, resulting in thinner skin and halted hair follicle growth, while later stages of epidermal growth may operate independently of basal progenitor division orientation.

research BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

84 citations , October 2014 in “PLoS Genetics”

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.

research 1397 LSD1 is critical for epidermal development and skin barrier formation

April 2023 in “Journal of Investigative Dermatology”

This study found that LSD1 is crucial for embryonic skin barrier formation in mice, revealing its significant role in epidermal development and suggesting its potential as a target in skin diseases with barrier defects.

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Community Join

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community Does applying Epidermal Growth Factor (EGF) make a difference in hair growth?

4 upvotes 3 years ago

Applying Epidermal Growth Factor (EGF) topically may improve skin and potentially promote scalp health and hair growth, especially after microneedling. The user shares their positive experience with EGF and provides a product link.

community Topical Metformin for Hair Transplant donor area skin/hair regeneration?

4 upvotes 1 year ago

Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

community Another molecular pathway to promote scarless healing and regenerate hair follicles

14 upvotes 8 months ago

Carnosic acid in rosemary extract may enhance skin repair and promote hair follicle regeneration. It could be used alone or with verteporfin for scarless healing after dermal wounding.

community I've seen this story around social media, and was surprised when I actually read it that the miracle cure in this case was exosome therapy, which I've previously tried for hairloss with little luck.

226 upvotes 2 months ago

Exosome therapy showed promising results for burn recovery but was less effective for hair loss. The conversation highlights skepticism about the visible results due to makeup and discusses the complexity of treating hair compared to skin.

community How to take care of the microneedler?

in Microneedling 7 upvotes 1 year ago

Disinfecting microneedlers is important to prevent infection, with suggestions to use high-percentage alcohol or denture tablets for sterilization. Rollers may cause skin damage, so stamps or pens are recommended for safer microneedling.

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Clinics

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61
Hair TransplantDermatology
Epiderma Skin and Hair ClinicBengaluru, Karnataka · IN

Learn

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learn Epidermal Growth Factor

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Experts

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36
SMP Specialist
Noelle Skin
Nice, France

Noelle Skin