TLDR ZIP10 is crucial for skin development and maintaining healthy skin.
The study demonstrated that the zinc transporter ZIP10 was crucial for epidermal development, particularly in hair follicles, by facilitating zinc homeostasis and supporting the activity of the transcription factor p63. ZIP10 was essential for the proliferation and maintenance of epidermal progenitor cells, with its zinc delivery necessary for proper p63 transactivation, vital for epidermal morphogenesis. The research highlighted ZIP10's role in regulating LGR6+ hair follicle stem cells and maintaining hair follicle structures. Mice lacking ZIP10 exhibited severe skin abnormalities, emphasizing its importance in epithelial homeostasis. The findings suggested ZIP10 as a potential therapeutic target for skin diseases, underscoring the significance of the ZIP10–zinc–p63 signaling axis in epidermal and hair follicle development.
133 citations
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September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
179 citations
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April 2012 in “Nature Communications” Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.
55 citations
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March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
19 citations
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February 2018 in “Nutrients” Certain zinc transporters are essential for healthy skin and managing zinc in the body could help treat skin problems.
4 citations
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December 2020 in “International journal of research - granthaalayah” Tetracycline can stick to hair follicles and potentially cause hair loss.
4 citations
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December 2022 in “International Journal of Molecular Sciences” Zinc is crucial for skin health and treating various skin disorders.
10 citations
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September 2023 in “Metabolites” Iron is crucial for skin health, with specific proteins recycling it to support skin functions and prevent its release.
4 citations
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January 2023 in “Frontiers in Medicine” Zinc is important for skin health, and supplements can help treat various skin and hair disorders, but more research is needed for conditions like psoriasis and vitiligo.
