Skin Structure

March 2015 in “ Plastic and reconstructive surgery ”

A. Barker

epidermis dermis hypodermis hair follicles sebaceous glands stem cells p63 signaling Notch signaling skin pigmentation aging Ehlers-Danlos syndrome epidermolysis bullosa stem cell therapies collagen injections skin layers hair roots oil glands stem cell treatments collagen shots

TLDR Human skin has multiple layers and functions, with key roles in protection, temperature control, and appearance.

The document provided a comprehensive overview of human skin structure and function, detailing the epidermis, dermis, and hypodermis layers, and their roles in protection, thermoregulation, and aesthetics. It emphasized the importance of hair follicles, sebaceous glands, and stem cells in skin regeneration and homeostasis. Key molecular processes like p63 and Notch signaling were highlighted for their roles in epidermal differentiation. The document also discussed skin pigmentation, the impact of aging, and various skin diseases, including Ehlers-Danlos syndrome and epidermolysis bullosa, along with potential treatments such as stem cell therapies and collagen injections.

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7 / 7 results

research Development and Homeostasis of the Sebaceous Gland

107 citations , October 2012 in “Seminars in Cell & Developmental Biology”

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research Epidermal Stem Cell Diversity and Quiescence

168 citations , August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin

1039 citations , February 2009 in “Nature Reviews Molecular Cell Biology”

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion

253 citations , April 2008 in “Current opinion in cell biology”

Notch signalling helps skin cells differentiate and prevents tumors.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

2 / 2 results

research Oral Tofacitinib: A Promising Treatment in Atopic Dermatitis, Alopecia Areata, and Vitiligo

37 citations , October 2017 in “Clinical and Experimental Dermatology”

Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.

research Common Dermatologic Conditions

14 citations , May 2014 in “Medical Clinics of North America”

The document concludes that quick referral and appropriate treatments are crucial for managing common skin conditions and preventing permanent damage.